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Objective To demonstrate the validity of volumetric QCT and dual energy X-ray absorptiometry( DXA )in bone mineral density (BMD) measurement and compare the difference in discriminating osteoporotic postmenopansal women with and without vertebral fracture. Methods One hundred and eighteen postmenopausal women [ mean age (62. 1 ± 7.0) years ] who received thoracolumbar radiographic examination were enrolled and divided into four groups (normal, osteopenia, osteoporotic and osteoporotic fractured group) also based on their BMD value of lumbar vertebra(AP-SPINE) measured by DXA: >x- 1s,x- 1s-x-2s, <x-2s without and with osteoporotic vertebral fracture. The second to four lumbar vertebrae were performed axial scan (for conventional 2D trabecular BMD measurement, 2D-TRAB by corresponding QCT software) and volumetric scan using MSCT. The volumetric data were transferred to the workstation ADW4. 2 for VR and MPR processing, and volumetric BMD were obtained based on the histogram of CT value, including integral BMD (3D-INTGL), cortical BMD (3D-CORT) and trabecular BMD (3D-TRAB), with the unit of mg/cm3. Apparent bone volume to total volume ratio ( App BV/TV% ) was calculated on the base of trabecular bone whose CT values were among 60 HU, 80 HU, 100 HU, 120--400 HU, respectively. Analysis of covariance (ANCOVA) and calculation of coefficient of determination ( R2 ) were performed for each parameter among the 4 groups. Results The values of 2D-TRAB, 3D- INT, 3D-TRAB, App60 BV/TV%, App80 BV/TV%, App100 BV/TV% and App120 BV/TV% in osteoporotic fractured group [(48.8±24.9) mg/cm3, (94.4±20.2) mg/cm3, (59.3±28.0) mg/cm3, (56. 1 ± 22. 8)%, (43.2±22. 2)%, (31.3±19. 4)%, (21.3±15. 6)% ] were significantly lower than those in osteoporotie group [ (74.9 ± 21.0) mg/cm3, ( 115.0 ± 14. 3 ) mg/cm3, (82. 0 ± 23.7) mg/cm3, (75.2 ± 16.8)%, (62.6 ± 20.5)%, (48.8 ± 21.7)%, (35.5 ± 20.1)%], osteopenia group [(89.2 ± 23.8) mg/cm3,(126.9 ± 12.9)mg/cm3, (97.8±25.2) mg/cm3, (85.1±13.7)%, (75. 1±17.9)%, (62.8±20.9)%, (49.2±21.9)%], and normal group[(120.6 ± 19.4) mg/cm3, (154.0 ± 16.3) mg/cm3, (131.1±21.1) mg/cm3, (95.6±5.3)%, (91.4±8.7)%, (84.7 ± 12.4)%, (75. 2 ± 15.5) % ], P <0. 01, respectively. For DXA parameter, there was no significant difference of AP-SPINE values found between osteoporotic fractured group [(0. 84±0. 16) g/cm2] and osteoporotic groups [ (0. 85±0. 06) g/cm2 ,P >0. 05 ]. In osteoporotic groups, AP-SPINE was not correlated significantly with other variables except 3D-CORT ( R2 = 0. 189, P < 0. 01 ) ; parameters of App60,80,100,120 BV/TV% were correlated significantly with 3 D-TRAB (R2 = 0. 955, 0. 951,0. 941,0. 912, P < 0. 01, respectively) and 2 D-TRAB(R2 = 0.912, 0.910, 0.878, 0.821, P < 0.01, respectively). The precision of 3D-BMD measurement was between 0. 70%--2. 25%. Conclusions Parameters derived from 3D-vQCT technique can discriminate osteoporotic postmenopausal women with fractured vertebrae from those without fractured vertebrae, and have better the capability than DXA. Among them, 3D-INTGL was the best parameter for diagnosing serious osteoporosis. App BV/TV% could be used to reflect the lost of trabecular bone precisely and to clinically predict fracture risk.
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0.05). The difference of CT values among the regions of middle portion had statistical significance(F=4.539,P
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In this paper,we analysed the plain film of spine and CT bone mineral density(BMD)of lumbar vertebral body in 63 Chinese osteoporotic women. There are 29 and 34 cases with and without fracture respectively in these patients. The average value of BMD in the fracture group was markedly lower than that of the non fracture group (P=0.0006).We suggested that 95mg/cm￣3 may be taken as an appropriate fracture threshold for Chinese elderly women, There were 18 and 45 cases with and without heterogenous calcification respectively in these patients.A significant difference of BMD was found between the two groups(P
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In this paper , 2280 strains of suspicious Shigella c culture were detected by the diagnostic typing phage set for Enterobacteriaceae, the routine identification of them were carried oat at the same time . The results showed that 100% of shigella cultures were lysed with 10~3RTD and 99.9% lysed with 1RTD of phage Sh. 12.3% of 65 non-shigeUa cultures agglutinating with typing serum of shigeUa was lysed with 10~3RTD, 4.6% lysed with 1RTD of phage Sh. The determination of lytic-pattern of 2215 shigella culture indicated that only 3 strains of Boyd 5 of lytic-pattern 3 were not reported in literature, the rest strains were consistent to fomer studies. The nonshigella cultures lysed by Sh 10~3RTD could be excluded with 1RTD and its lytic-pattern. 20 strains of Enteroinvasive Escherichia coli possessing shigeUa-related antigens could be differentiated by Sh 10~3RTD. 1RTD and its lytic-pattern.